Adam Lallana, Dale Stephens and Dan Harding will be checked over ahead of Southampton's trip to Leyton Orient.
Lallana was taken off as a precaution with a tight groin at Charlton on Tuesday night and should be fit.
But fellow midfielder Stephens is a major doubt after taking a nasty knock to his Achilles on his full debut.
Harding missed the win at The Valley with a groin strain and Ryan Dickson will continue at left-back if he is ruled out again.
Midfielder Morgan Schneiderlin (knee) and wingers Alex Chamberlain and Lee Holmes (both ankle) remain on the sidelines.
Veteran striker David Connolly made his first appearance in four months as a substitute in midweek following groin trouble and should be on the bench again.