Southampton boss Alan Pardew may have to make do without Morgan Schneiderlin for the trip to Wycombe.
The midfielder picked up a knock in the 2-0 victory over Norwich on Saturday and is rated doubtful.
Defender Dan Seaborne is out as he is undergoing scans to find the extent of a knee injury which has kept him out of Saints' past three matches.
The game comes a week too soon for striker David Connolly who will once again miss out with the groin injury which has sidelined him since December, but he could be back for the weekend game against Walsall.
Defender Graeme Murty remains sidelined and is unlikely to feature again this season following ankle surgery last week.