Southampton will be without January signings Jose Fonte, Dan Seaborne, Jon Otsemebor and Jason Puncheon for the FA Cup south-coast derby meeting with Portsmouth.
Defenders Fonte, Seaborne and Otsemebor and winger Puncheon are all cup-tied so Wayne Thomas, Chris Perry and Radhi Jaidi come in at the back and Michail Antonio should start on the flank.
A fifth new recruit, striker Lee Barnard, is available and returns to the squad having been ineligible for the midweek Johnstone's Paint Trophy win over MK Dons.
Boss Alan Pardew will check on forward David Connolly, who has been out since December with a niggling groin injury but is close to returning.
Veteran full-back Graeme Murty remains on the sidelines with ankle ligament damage.