Southampton can welcome back Morgan Schneiderlin, Jose Fonte, Dan Seaborne and Jon Otsemobor for the trip to Brentford.
Schneiderlin has had the three-match ban he received for his recent red card against MK Dons reduced to one game, and having missed Saturday's FA Cup win over Ipswich is available at Griffin Park.
Defenders Fonte, Seaborne and Ostemobor were all cup-tied at the weekend and will come back into contention.
Their availability will give manager Alan Pardew a selection dilemma at the back with centre-half Radhi Jaidi returning on Saturday after an eye injury and makeshift right-back Wayne Thomas scoring Saints' opening goal.
Midfielder Dean Hammond is set to miss out again with an Achilles injury and striker David Connolly remains a doubt with groin trouble.