Adam Lallana is expected to return to the Southampton starting line-up for the visit of Bristol Rovers.
Saints' star midfielder played the final 17 minutes of Tuesday night's 2-0 defeat at Rochdale to prove his fitness after a groin injury.
Defender Dan Harding looks set to miss out after limping off with a groin problem just before half-time.
Ryan Dickson should therefore revert to left-back leaving a spot in the midfield for Lallana.
Richard Chaplow will return to the squad after he was rested in midweek but fellow midfielder Morgan Schneiderlin (knee) and winger Alex Chamberlain (ankle) will not be risked.
Saints remain in the second automatic promotion place despite falling to their first defeat in nine matches at Spotland.