Dan Harding has a chance of being fit for Southampton when Hartlepool visit St Mary`s.
The left-back has been nursing a groin problem but could return to the squad after he was close to being included against Brighton on Saturday.
Winger Alex Chamberlain is unlikely to recover from an ankle injury in time, while Lee Barnard will remain on the sidelines.
The 16-goal striker was taken to hospital with an ankle injury during the victory over Bristol Rovers and could struggle to play again this season.
Adam Lallana has been struggling with a groin tear lately but came on as a half-time substitute during the win over newly-crowned champions Brighton and could be restored to the starting line-up.