David Connolly is set to miss Southampton's trip to Sheffield Wednesday.
The veteran striker has been struggling with a stomach injury all week and is unlikely to be involved at Hillsborough.
Rickie Lambert and Lee Barnard will continue in attack as Saints look for their first goal in seven and a half hours.
Defender Aaron Martin has missed the last two games with a back problem but has trained this week and could return.
Midfielder Adam Lallana has begun light training but is still a couple of weeks away from a comeback after undergoing knee surgery earlier this month.
Full-back Frazer Richardson remains on the sidelines following a dislocated shoulder but he too has been pencilled in for a return in October.