Southampton will be without Lee Barnard when they head along the south coast to meet champions Brighton.
The 16-goal striker was taken to hospital with an ankle injury during Saturday's 1-0 win over Bristol Rovers and could struggle to play again this season.
Winger Alex Chamberlain is set to miss out again with an ankle problem while left-back Dan Harding is a doubt with a groin injury.
Adam Lallana has been struggling with a groin tear lately but could come back into the starting line-up after he was rested last week.
Richard Chaplow may also be recalled after sitting on the bench against Rovers but fellow midfielder Morgan Schneiderlin (knee) and winger Lee Holmes (ankle) are still missing.