Lee Barnard returns for Nigel Adkins' first home game in charge of Southampton against Colchester.
Barnard has completed a three-match ban for his sending-off against Swindon last month.
He could go straight back into the starting line-up as Adkins attempts to pep up an attack which has yet to find the net since Alan Pardew was sacked four games ago.
Defender Aaron Martin missed Wednesday night's 2-0 defeat by MK Dons with a back injury and will be checked over.
Full-back Frazer Richardson (shoulder) and midfielder Adam Lallana (knee) are still on the sidelines.
Radhi Jaidi, Ryan Dickson and Guly Do Prado could be involved if Adkins opts to make further changes while skipper Dean Hammond plays against his former club.