Upson in for Albion
Jeremy Helan could go straight back into Sheffield Wednesday's starting line-up for the home game with Brighton.
The French midfielder recently went back to parent club Manchester City at the end of his initial loan spell, but has returned to Hillsborough until May.
But manager Dave Jones, who has several selection dilemmas, could opt to start with Helan on the substitutes' bench following the display last week of Danny Pugh, who recently arrived on loan from Leeds.
Another recent loan signing, Swansea striker Leroy Lita, could also force his way into Jones' starting line-up. He scored the winner after stepping off the bench on his Owls debut at Charlton.
Jones, who has no new injury or suspension worries, must decide whether to stick with Jermaine Johnson and Michail Antonio up front or hand Lita his full debut.
Wednesday, four points clear of the bottom three, are chasing their first home win in four matches.
Matthew Upson could make his Brighton debut after his deadline-day switch from Stoke.
Boss Gus Poyet snapped up the former England defender as Seagulls skipper Gordon Greer faces a spell out with a hamstring injury suffered during last weekend's 3-2 FA Cup defeat by Arsenal.
Right-back Bruno could finally be fit following a month on the sidelines with an Achilles problem, while winger Will Buckley is expected to be available despite coming off against Arsenal after feeling a twinge in his hamstring.
Tomasz Kuszczak returns in goal after Casper Ankergren got another run-out in the cup.
Striker Stephen Dobbie has joined Crystal Palace on loan while defender Romain Vincelot and youngster Matt McGiveron have been released.