Sheffield Wednesday's recent signings Michael Morrison and Reda Johnson are expected to make their home debuts against Charlton.
The 22-year-old defenders, both signed on a permanent basis for undisclosed fees from Leicester and Plymouth respectively last week, went straight into the starting line-up at Bristol City on Saturday.
The Owls are still without defenders Jon Otsemobor (calf) and Lewis Buxton (hamstring), so Morrison is likely to start again at right-back.
Midfielder Giles Coke has returned to full training following his recent knee operation, but will not be in contention this weekend, so James O'Connor could partner Tommy Miller again in central midfield. Darren Potter is also in contention.
The Owls, 3-0 winners in their FA Cup clash at Bristol City, have lost their last two league matches.