Owls manager Alan Irvine will be keen to have Mellor available as his side look to recover from back-to-back defeats.
"We missed having him as one of our options against Carlisle," the Wednesday boss told the Star.
"You always want to see more strength in your squad rather than less. "He would have played at some point during that game, whether that was starting or coming on.
"What happened was just bad timing. If he'd picked this up early in the week, he'd have been okay for last Saturday."