Striker Richard Cresswell is the latest casualty at Bramall Lane after suffering a shoulder problem in Monday's 2-2 draw with Doncaster which will keep him out for four to six weeks.
Midfielder Stephen Quinn continues his three-match ban after a red card for his part in the melee at Norwich and he is joined by loanee Andy Reid, who received a retrospective ban for his involvement in that scuffle, though he would not have been eligible to play anyway.
Matty Lowton (groin), Richard Wright (thigh), Nyron Nosworthy and Stephen Jordan (both ankle) are sidelined while Jordan Slew will be assessed after reporting ill on Thursday.
Aston Villa's new signing, right-back Kyle Walker, is included in the squad against his former club.
Walker has joined Villa on loan from Tottenham for the remainder of the season. He spent the first half of the campaign on loan at QPR.
Villa striker Emile Heskey will start a three-match suspension tomorrow for his straight red card against Sunderland in mid-week.
He will also miss the derby with Birmingham at St Andrew's and the home encounter with Manchester City.
Gabriel Agbonlahor is set to switch from a wide role into the main striking role.
But defender Luke Young and midfielder Fabian Delph are still side-lined with knee injuries.