Stephen Jordan is expected to miss the derby clash at Doncaster due to a hamstring strain.
The Blades defender sustained the injury in the midweek win at Hull and is expected to be replaced by Ritchie De Laet, on loan from Manchester United, in the starting line-up.
The Blades will also be without midfielder Nick Montgomery again as he has had an injection in a bid to resolve an Achilles problem, while striker Ched Evans remains sidelined due to a recurrence of his groin injury.
Striker Jamie Ward is pushing for a return to the starting line-up, but manager Gary Speed is expected to keep faith with Richard Cresswell and Daniel Bogdanovic up front following Tuesday night's success.
The Blades are hoping to climb into the top half of the table with their third league win of the season away from home.