Captain Lee Frecklington will miss out for Rotherham's match with Oxford
Rotherham will be without skipper Lee Frecklington for the home clash with Oxford.
Frecklington hurt his ankle in Monday's 2-0 defeat to Leeds and will not be risked for the FA Cup tie.
The Millers have no fresh injury concerns, but have been hit hard by news that goalkeeper Lee Camp will miss the remainder of the season with a knee injury.
The first few days of the transfer window have seen Dominic Ball join Peterborough while Dael Fry and Jake Forster-Caskey have had their loans cut short.
Northampton could hand full debuts to recent loan acquisitions Gregg Wylde, of Millwall, and Crystal Palace midfielder Hiram Boateng.
Wylde came off the bench in the 2-1 home defeat to Bradford on Monday and may come into Rob Page's thinking for the trip.
Having lost four of their last five games in all competitions, Page could yet decide to make more changes, with the likes of Harry Beautyman and Joe Iaciofano also waiting in the wings.
Meanwhile, defender Brendan Moloney (knee) and striker JJ Hooper (thigh) are once again expected to miss out for the Cobblers.