Sporting director Emilio Butragueno insists Real Madrid will exercise caution with the returning Cristiano Ronaldo.
The £80million winger has been sidelined for seven weeks with an ankle injury, but is scheduled to resume full training this weekend.
Ronaldo is reported to have set his sights on making his comeback against Barcelona on November 28, but Real will not rush the world's most expensive player back into premature action in time for the Clasico.
"I feel that Cristiano wants to play now and that enthusiasm can be detrimental because a relapse would be scary," said Butragueno.
"We must go slowly as Cristiano has had many days without training. It's not enough that the ankle is good but it must have the necessary reinforcement to compete.
"Cristiano Ronaldo is a great professional, he is a winner and has a commitment to the club and does everything possible to return, but when he returns he cannot have a relapse."