Real Madrid face Barcelona in a make-or-break El Clasico on Sunday aided by a resurgent Cristiano Ronaldo but acutely aware that defeat would see them trail their bitter enemies by a massive 11 points.
Ronaldo has hit form at just the right time, netting three in the 4-1 win at Ajax in the Champions League on Wednesday, that haul coming after his hat-trick in the 5-1 La Liga rout of Deportivo La Coruna last weekend.
The last time Real and Barcelona clashed in the league last April, Ronaldo scored the decisive goal at the Camp Nou as Madrid went on to win the league.
But this season Barcelona have begun with ominous intent to reclaim their crown with six straight victories.
Perhaps the result of basking in their own triumph, Jose Mourinho's side instead made a stuttering start with just one win from the first four games but since then they have clicked into gear and Ronaldo has looked more like his old self.
The Portuguese had looked moody and introspective, refusing to celebrate some goals with his team-mates and declaring himself unhappy but his winner against Manchester City in the Champions League last month showed his desire was back.
And now he is fully primed to face Barca after his successive hat-tricks.
"I am very happy with the way we are playing and the victory against Ajax gives us all plenty of confidence while for me personally to score three is vital for my own confidence," said Ronaldo.
"We will go to the Camp Nou which is a very difficult stadium but we have belief in our chances and that we can get a good result. Barca have a very strong side with strength in depth."
His teammate Xabi Alonso admitted that there is no margin for error.
"To win will be fantastic and lose, bad, there is no way of hiding the fact. We are aware of the difference in points and so obviously we are going out for the victory but we need to rest and prepare," he said.
Although Barca have a 100 per cent record they have had injury worries to deal with especially in defence.
And the bad news to come from their mid-week Champions League win over Benfica was that Carles Puyol will be out of action for up to two months with a dislocated elbow.
The talismanic defender was only just returning from a lengthy layoff and is now back in the treatment room along with fellow centre-half Gerard Pique, so it is likely that Javier Mascherano and Alex Song will line up in the heart of the defence on Sunday.
Elsewhere unbeaten duo Atletico Madrid and Malaga go head-to-head while high-flying Mallorca are against Granada.
On Friday, Celta Viga made it three home wins in a row after defeating Sevilla, 2-0.
Saturday, Real Betis bounced back from two straight defeats with a 2-0 win over Real Sociedad on a black night for La Liga which saw five red cards brandished in just four matches.
A second half Diego Castro penalty gave Getafe a 1-0 victory away to Zaragoza in a stormy game which featured three sendings off.
Rayo Vallecano beat Deportivo la Coruna 2-1 with goals by Francisco Piti and Jose Carlos while Luis Miguel Pizzi pulled one back from the penalty spot.
Ten-man Espanyol picked up only their second point of the season after a 1-1 draw away to Valladolid.
Sunday's fixtures (all times GMT)
Levante v Valencia (1000), Mallorca v Granada (1400), Athletic Bilbao v Osasuna (1600), Barcelona v Real Madrid (1750), Atletico Madrid v Malaga (1930)