McAnuff will start a three-game ban against the Owls - which also rules him out of the cup tie with Aston Villa - to leave McDermott with a selection headache.
McAnuff and Jimmy Kebe have excelled in wide roles in recent weeks and with no other out-and-out wingers available, Brian McDermott may have to change formation.
Midfielder Gylfi Sigurdsson returned to the starting line-up at The Hawthorns after a recent foot injury and scored the winner so should continue, while striker Shane Long serves the fourth and final game of his suspension.
Midfielder Jem Karacan has had an operation on his broken hand and could be out for several weeks, while Brynjar Gunnarsson (dead leg) and Kalifa Cisse (groin) could be involved. McDermott also has on-loan Blackburn defender Zurab Khizanishvili available again.