Coca Cola Championship
Venue: Hillsborough Date: Tuesday, 20 October 2009 Kick-off: 1945 BST
Coverage: BBC Sport website, BBC Radio 5 live, BBC local radio
Sheffield Wednesday could be boosted by the return of Richard Wood, Marcus Tudgay and Etienne Esajas.
Wood missed the win against Coventry through illness, while Tudgay has had a neck problem and Esajas was ruled out with a knee injury.
Preston captain Callum Davidson may make his long-awaited return from the hamstring injury which has kept him out since last month.
Paul Parry could start after his recent hamstring problem.
Preston are looking to atone for a terrible performance on Saturday at QPR, where they were thrashed 4-0.
Following the sale of defender Sean St Ledger and some disappointing recent results, the return to full fitness of key players like Callum Davidson, Richard Chaplow and Paul Parry will be a much-needed boost for boss Alan Irvine.
They now face a Sheffield Wednesday side that ended a poor run of home form by beating Coventry 2-0 at the weekend.
Manager Brian Laws described that performance as "exceptionally good" and another win for the Owls would take them above Preston in the table.
• These clubs are meeting in a competitive match for the 99th time.
Have your say on this match
• They have faced each other 88 times in the league. Wednesday have won 34 matches and Preston 35 with 19 drawn.
• Both last season's meetings were 1-1 draws.
• Wednesday are aiming for a third successive home league win.
• The Owls have won four, drawn four and lost four of their 12 league games this season.
• A win for Wednesday would be their 50th in a league game under manager Brian Laws and a loss would be their 50th league defeat under him.
• Laws has used 19 players in this Championship campaign, which is the joint fewest alongside Nottingham Forest.
• If he plays, Jermaine Johnson will be making his 100th appearance for the Owls.
• Preston have picked up one point from the last nine available and have failed to score in their last two matches.
• North End are on their longest winless sequence of the season so far.
• If selected, Chris Sedgwick will be making his 450th career league appearance.
MOST RECENT MEETING
Preston 1-1 Sheff Wed (11 March 2009)
Preston scorer: Parkin 90.
Wednesday scorer: Jeffers 30.