Vale have been one of the Carling Cup's biggest giantkillers this season, knocking out Sheffield United on their own patch before seeing off city rivals Wednesday in the last round.
Adams and his charges will now look to continue their exploits at Glanford Park as they come up against an Iron side who sit safely in mid-table in the Championship.
Assistant player/manager Geoff Horsfield remains sidelined with the groin strain he picked up in training on Friday, with Adams not expecting to see the striker in a playing capacity for another couple of weeks.
Fellow forward James Lawrie has returned to training after having his appendix out but this game is expected to come too soon for him, while goalkeeper Joe Anyon continues to make progress with his recovery from a broken leg.
Midfielder Dave Howland may again find himself on the bench having showed plenty of character since finding himself on the transfer list at the start of the season.