Port Vale assistant manager Geoff Horsfield is confident striker Marc Richards and midfielder Doug Loft will shake off injury knocks in time to face Southend.
Richards opened the scoring against Chesterfield in last weekend's 1-1 draw but left the action in the second half with knee and ankle injuries.
Vale missed a host of chances to make the game safe before Loft also exited proceedings with bruised ribs.
"Marc is looking okay but we don't know if he'll definitely be fit for Saturday," Horsfield told the Sentinel.
"Him and Doug both had a couple of days off training this week but they're fit lads."
Boss Micky Adams must decide whether to stick with a 4-4-2 formation or revert to the 3-5-2 system which impressively overcame QPR in the Carling Cup.