Plymouth boss Peter Reid will again be without Jim Paterson, Onismor Bhasera and Yala Bolasie for the important clash with fellow relegation battlers Tranmere.
Paterson missed the defeats to Yeovil and Brentford as he was on compassionate leave and will be absent again, although he will return to training on Monday.
Bhasera is making good progress in his rehabilitation from a knee problem but the game will come too soon for him while Bolasie will sit out the second game of a three-match ban following his sending-off against Yeovil on February 1 for an off-the-ball incident.
However, top scorer Joe Mason is set to continue in attack after getting through his comeback from an ankle injury against Brentford unscathed.
The Pilgrims will be attempting to end a run of four successive league defeats.