Plymouth manager Peter Reid will include Carl Fletcher, Kari Arnason and Rory Fallon in his squad for the trip to Dagenham.
Captain Fletcher limped out of last weekend's 2-1 defeat at Peterborough with an ankle problem but has recovered sufficiently to take his place in the travelling party.
Utility-man Arnason and striker Fallon have been suffering from ongoing groin problems in recent weeks but have again declared their availability despite not being fully fit.
"They are not 100%, but the season's coming to an end and they are still fighting," Reid told the club's official website. "They still want to go out there and put the shirt on, which is fantastic."
The Pilgrims boss has no other injury or suspension concerns for the must-win game.