Plymouth boss Adams set to stick with winning line-up
Plymouth manager Derek Adams could stick to the same starting line-up that claimed a 3-0 derby win over Exeter last time out.
Adams handed home debuts to centre-back Jakub Sokolik, midfielder Antoni Sarcevic, winger Matt Kennedy and striker Ryan Taylor, who got on the scoresheet, and all four impressed.
Jimmy Spencer may feature after he returned to the matchday squad following a long-term ankle injury. Ryan Donaldson, who has recovered from a broken jaw, could also be in contention.
Gary Miller and Connor Smith (both ankle) and David Ijaha (pelvis) are still unavailable.
Leyton Orient boss Danny Webb could make a few changes to his side for the trip to the south west.
Liam Kelly was handed his first start since October against Yeovil and could continue in midfield after the O's claimed their first point under Webb.
Defender Callum Kennedy is set to start after replacing Yvan Erichot at half-time during their 1-1 draw at Yeovil.
Paul McCallum could be in contention for a recall after returning from a knee injury while youngsters Victor Adeboyejo and Sam Dalby are pushing for starts.