Peterborough will be without striker Craig Mackail-Smith for the visit of Leyton Orient.
The 26-year-old has scored 12 goals this season but collected his fifth booking during Saturday`s 4-1 defeat at Southampton and will serve a one-match ban.
That will see Lee Tomlin pushed forward to partner Aaron Mclean in attack as Dave Hibbert remains a long-term absentee.
Hibbert dislocated his knee after coming off the bench during the 4-1 FA Cup replay win over Stockport last week and is set for several months on the sidelines.
Full-backs Nana Ofori-Twumasi and Tommy Rowe are out with groin strains while midfielder Lee Frecklington rounds out the absentees after he suffered ankle ligament damage.
Manager Gary Johnson is set to make changes to his starting XI after the latest heavy defeat at St Mary`s with Gabriel Zakuani, James Wesolowski, Ryan Bennett, Nathaniel Mendez-Laing and Adam Clayton all hoping for recalls.