Peterborough striker Junior Morias has been ruled out for up to five months ahead of the visit of Oxford.
Morias was carried off during the first half of the 3-2 midweek defeat at Oldham and boss Grant McCann has revealed he has ruptured his thigh.
Midfielder Anthony Grant is available again following a one-match suspension, but Gwion Edwards remains sidelined as he recovers from a groin strain.
Callum Chettle continues his rehabilitation from a hamstring problem.
Oxford boss Pep Clotet could look to make changes following a third straight Sky Bet League One defeat - a 3-0 reverse at Bury on Tuesday night.
Forward Agon Mehmeti, midfielder Joe Rothwell and Jack Payne, who is on loan from Huddersfield, could all come into contention.
Defender Christian Ribeiro has been out since the start of September with a knee injury, but is back in full training, while striker Jon Obika has been carrying a groin problem.
Dutch international Dwight Tiendalli is closing in on a return from his hamstring injury.