Lewis was at fault for Huddersfield's opening goal in the 3-2 defeat in midweek but will be between the posts against Pools.
Captain Grant McCann is away on international duty with Northern Ireland but is also serving the third and final game of his suspension while Lee Frecklington could keep his place.
Frecklington returned to the starting line-up at Huddersfield after a knee injury and lasted the whole 90 minutes to put himself in contention.
Former Stockport winger Tommy Rowe - who has been playing at full-back this season - came off at half-time in last weekend's 1-0 win at Carlisle nursing a groin injury and is out.
That leaves record signing Ryan Bennett and midfielder James Wesolowski (both knee) as the only other injury victims at London Road.