Oxford will be without defender Jake Wright for their home match with Barnet.
Centre-back Wright will be unavailable after he was ruled out for up to eight weeks with a broken metatarsal sustained in the 2-1 win over Chesterfield last week.
Harry Worley replaced Wright just before half-time against Chesterfield and is expected to continue at the heart of defence.
On-loan Plymouth striker Steven Maclean is likely to lead the line again and will now stay at the Kassam Stadium until January 15 after his loan deal was extended.
Leading goalscorer James Constable is pushing for a return to the side after making substitute appearances in the last three matches following his recovery from illness.