Oxford manager Chris Wilder will be boosted by the return of Jake Wright from suspension when his side host Gillingham.
The 24-year-old centre-back missed the defeats to Torquay, Burton and Rotherham after receiving his marching orders for violent conduct during the 5-0 loss against Bradford in October.
However, he is expected to go straight back in alongside Ben Futcher, who will be making his home debut after signing on loan.
Fellow loanees Paul Wotton and Steve MacLean are also likely to make their home debuts, with the latter expected to continue in attack alongside James Constable who is back to full fitness after missing the Torquay game and only making the bench against Rotherham due to illness.
Midfielder Sam Deering is unavailable after completing a loan move to Conference side Newport. He will stay with the South Wales club until January.
Alfie Potter and Tom Craddock will be vying for the other forward place if Wilder sticks with a 4-3-3 formation but he could revert back to the 4-4-2 used in the 1-0 defeat at Burton.