Oxford manager Chris Wilder has no new injury or suspension problems for the trip to Chesterfield.
However, he could be tempted to make changes as he looks to halt a run of five defeats in a row in all competitions.
The Us started Saturday`s 1-0 defeat against Gillingham in a 4-3-3 formation with loanee Steven Maclean leading the line with Alfie Potter and Tom Craddock playing on the wings, but Wilder may be tempted to change to 4-4-2.
James Constable made his comeback from illness with a 45-minute appearance at the weekend and will be hoping to partner Maclean up front.
Josh Payne could therefore drop to the bench with Tom Craddock moving to a wide midfield role.