Oxford's leading scorer James Constable may have to settle for a place on the bench for the clash with Aldershot.
United boss Chris Wilder opted for the strike pairing of Jack Midson and Tom Craddock in Monday's 4-3 victory at Torquay and Midson took his chance by scoring a hat-trick.
Wilder may opt to stick with the same duo against the Shots, meaning talisman Constable would once again be among the substitutes.
Midfielder Sam Deering and defender Mark Creighton could be in the squad after returning from loan spells at Newport County and Wrexham respectively.
Ben Futcher will play no part of returning to parent club Bury, while fellow defender Rhys Day has signed for Mansfield.
Defender Leigh Franks is a doubt due to a hamstring injury.