Oxford manager chris Wilder has three new players at his disposal for the trip to Rotherham.
Wilder has moved fast during the week to tie up loan deals for a trio of players who have a vast amount of Football League experience.
Defender Ben Futcher has joined from Bury, midfielder Paul Wotton has arrived from Southampton and striker Steven Maclean has signed from Plymouth and all three new signings are in contention to make their debuts against Ronnie Moore's men.
Jake Wright is unavailable as he serves the final game of his three-match suspension while Sam Deering and Asa Hall are both pushing for a start after their goals in midweek for the reserves.
Striker James Constable should return to the squad after missing the FA Cup defeat to Burton through illness.