Oxford will have striker Gino van Kessel available ahead of international duty for the Sky Bet League One match against AFC Wimbledon.
The on-loan Slavia Prague forward, who scored in the midweek Checkatrade Trophy draw with Brighton Under-21s, has delayed his departure to join up with the Curacao national team.
Defender Canice Carroll is is away with the Republic of Ireland under-19 squad, but striker Jon Obika could be available again after a groin problem.
Dutch defender Dwight Tiendalli is closing in on a return from a hamstring injury, while midfielder Rob Hall will be assessed on a groin strain.
AFC Wimbledon boss Neal Ardley is expected to bring back in his senior players after a young side beat Tottenham Under-21s 4-3 in the Checkatrade Trophy on Tuesday.
Midfielder Liam Trotter and forward Lyle Taylor both came off the bench, while fellow substitute Dean Parrett netted a stoppage-time winner against his former club.
Welsh defender Jonathan Meades has stepped up his rehabilitation following a long-term knee problem, so is close to being back in contention.
Ghana striker Kwesi Appiah, though, continues to recover from a hamstring injury.