Striker Ryan Doble is in line to make his Oxford debut against Bury.
The Southampton loanee is vying for a starting place after returning from international duty with Wales` Under-21s.
Midfielder Paul McLaren returned to the side for the 3-0 win over Burton after a lay-off with a groin injury but was substituted at the break.
Manager Chris Wilder confirmed that he will miss the game after receiving seven stitches in a cut just above his Achilles.
Josh Payne will get the nod in midfield, with the 20-year-old earning warm praise from Wilder, who labelled him "a really talented footballer" in an interview on the club's official site.
The U`s have won two matches in a row to boost their hopes of back-to-back promotions.