Oldham boss Paul Dickov could be without Chris Taylor and Filipe Morais for the trip to Colchester.
Winger Taylor has been struck down by mumps and missed Saturday's 1-0 home defeat to leaders Brighton.
Midfielder Morais is an injury doubt after sustaining a hamstring strain against the Seagulls and was replaced in the closing stages.
The result stretched Oldham's winless run to 10 games and striker Warren Feeney will miss the game with Colchester and next Monday's home clash against Tranmere.
Feeney has reported for Northern Ireland duty as they prepare for two Euro 2012 qualifiers in Serbia on Friday and at home to Slovenia next Tuesday.
It was initially thought Feeney would only miss the Tranmere match, but because of the five-day ruling he will now miss the trip to the Weston Homes Community Stadium.