Former Bluebirds striker Robert Earnshaw looks set to miss out against his old club as he continues to work his way back to fitness from a calf problem.
Fellow striker Dexter Blackstock will also remain out with the knee injury he suffered against Barnsley. He is not expected to be back in contention until after the international break in November.
James Perch, a surprise inclusion as a substitute at Selhurst Park last weekend, will miss out after suffering a setback in his recovery from a long-term shin problem.
The defender was due to play for the reserves in midweek but had to withdraw from the game after sustaining an ankle injury.
The match kicks off at 5pm.