Northampton boss Ian Sampson is likely to hand centre-back Ben Tozer his debut against Liverpool in the Carling Cup following his arrival from Newcastle on loan.
The 20-year-old should start with Dean Beckwith sidelined due to a thigh strain suffered before the Shrewsbury defeat, while Abdul Osman had to be replaced during the second half with a knee problem.
Tadhg Purcell will be out for most of the season following an operation on his cruciate knee injury while Craig Hinton also remains sidelined with a knee problem.
Midfielder Ryan Gilligan still requires surgery on an ankle problem and despite having been playing through the pain barrier, may be rested with Michael Jacobs a possible replacement.
Marcus Hall will also miss out again with a hamstring injury.