Oxford are set to include striker Steve MacLean, who has extended his loan spell from Plymouth.
Defender Djoumin Sangare is pushing for a start after making his a debut as a substitute in the 2-1 win against Bradford last week.
Northampton Town manager Ian Sampson told BBC Radio Northampton: "It's a big game on Saturday against Oxford, our local rivals.
"There'll be a big crowd. They're bringing some good away fans.
"I'm not having to rely on youth teamers filling the bench. Hopefully the pros will be fit and that will give me a few more options."