Aidy Boothroyd still maintained after the weekend defeat at Hartlepool that his side were on the up after some better recent results but the tame manner of the reverse in the North East gives little cause for optimism to those travelling to North East Derbyshire.
Chesterfield, 3-0 winners over Town in the corresponding fixture in January, lie second in League Two and trail leaders Oxford United on goal difference only.
They eased to victory against Wycombe Wanderers at home on Saturday and have conceded only seven goals in nine home league games to date this season.
Northampton are 5/1 to cause an upset against the 4/7 Spireites.
Source: Cobblers Mad