The Cobblers have won 35 of the 87 meetings to date including 11 away from home.
Last season's corresponding game, in early October, ended in a 3-1 win for the home side after Anthony Charles was sent off for Town early in the game.
Aidy Boothroyd has seen his side have a man dismissed in both their away league games this season and knows that any repeat will harm their chances of improving their form on the road.
Rovers head into the match in good spirits after a 3-2 win against York City last weekend.
"It is important we now build on what we achieved on Saturday by backing it up with another win against Northampton," defender Lee Brown told the Bristol Evening Post.
Source: Cobblers Mad