Newcastle United have lost their appeal against the red card shown to Sebastien Bassong in the 1-0 home defeat at the hands of Fulham at the weekend.
The on-loan stopper was dismissed by referee Howard Webb for a professional foul on Cottagers striker Diomansy Kamara an hour into the St James' Park reverse and will now sit out the crunch clash with Aston Villa.
The Magpies had hoped to have Bassong available for this Sunday's Villa Park encounter, with United needing at least a draw to have any chance of avoiding relegation from the top-flight.
An FA statement confirmed: "At a Regulatory Commission hearing a claim for wrongful dismissal by Newcastle United defender Sebastian Bassong was rejected.
"Bassong was sent off during Newcastle United's Premier League match with Fulham on Saturday 16 May for denial of an obvious goalscoring opportunity.
"Bassong's two-match suspension, due to it being his second dismissal of the season, begins with immediate effect."