With Aussie Bradden Inman playing out wide and Philip Airey expected to pose the lone threat up front, Newcastle are looking to improve on the 1-1 score from the first meeting eight days ago.
If the scores remain level after 90 minutes, the tie will head into extra-time and penalties for the right to meet Chelsea in the final.
NEWCASTLE UNITED (4-5-1): Alnwick; Tavernier, Henderson, Folan, Dummett; Ameobi, McDermott, Inman, Newton, Adjei; Airey. Subs (not used): Nzuzi, Robinson, Vuckic, Taylor, McGorrigan.
ASTON VILLA (4-4-2): Siegrist; Berry, Williams, Devine, Deeney; Taylor, Blythe, Carruthers, Roberts; Simmons, Poyser. Subs (not used): Nelson-Addy, Barrett, Cameron, Dyer, Johnson.