There are doubts over a key quartet of players, with strikers Papiss Cisse and Demba Ba and midfielders Yohan Cabaye and Hatem Ben Arfa all needing to have their fitness assessed, but defender Fabricio Coloccini should be able to play, despite suffering a knock in last weekend's friendly defeat to Cardiff.
Fellow centre-back Steven Taylor and midfielder Sylvain Marveaux are both back in the squad after long-term injury lay-offs, while new recruits Vurnon Anita, Curtis Good, Gael Bigirimana and Romain Amalfitano are available to make their debuts.
Newcastle (from): Krul, Elliot, Harper, Santon, R. Taylor, Ferguson, Tavernier, Perch, Coloccini, Williamson, S. Taylor, Simpson, Tiote, Cabaye, Ben Arfa, Gutierrez, Obertan, Marveaux, Abeid, Gosling, Vuckic, Ba, Cisse, Shola Ameobi, Sammy Ameobi, Anita, Good, Bigirimana, Amalfitano.
Wantaway playmaker Luka Modric is set to be left out of Tottenham's squad.
The Croatian, who is close to sealing a transfer to Real Madrid, has not played all summer after refusing to go on the club's pre-season tour of the United States and Spurs will not risk him getting injured in the game.
Jan Vertonghen and Gylfi Sigurdsson are likely to make their debuts, but Scott Parker (Achilles) and Heurelho Gomes (ankle) are out.
Tottenham (from): Friedel, Cudicini, Kaboul, Gallas, Dawson, Walker, Assou-Ekotto, Bassong, Vertonghen, Caulker, Naughton, Bale, Huddlestone, Lennon, Van der Vaart, Rose, Livermore, Sandro, Bentley, Jenas, Sigurdsson, Carroll, Townsend, Dos Santos, Defoe, Kane.