With Shola Ameobi nursing a knee injury, Nile Ranger will make his first Premier League start at Villa Park.
Ranger will partner Peter Lovenkrands in attack, and with Kevin Nolan suspended, Newcastle will also be lining up with a new-look midfield.
Fabricio Coloccini will move out of defence to play in the holding role at the base of midfield.
The Argentinian will play behind a trio of Joey Barton, Danny Guthrie and Jonas Gutierrez, with the recalled Steven Taylor plugging the gap at centre-half.
ASTON VILLA (4-2-3-1): Friedel; Walker, Dunne, Collins, L Young; Makoun, Petrov; Downing, A Young, Agbonlahor; Bent.
Subs: Marshall (gk), Clark, Cuellar, Pires, Albrighton, Reo-Coker, Heskey.
NEWCASTLE (4-1-3-2): Harper; Simpson, Williamson, S Taylor, Enrique; Coloccini; Barton, Guthrie, Gutierrez; Lovenkrands, Ranger.
Subs: Krul, Ferguson, Tavernier, Richardson, R Taylor, Donaldson, Kuqi.