The 24-year-old, who has scored six goals this season from 10 starts, had missed the Magpies' last two games with the injury.
Best consulted the club's medical staff and it was decided he should travel to London for the operation.
Agony: Best has now been ruled out for the remainder of the season with a knee injury
Alan Pardew must now rely on Peter Lovenkrands and youngster Nile Ranger for the remainder of the season, after the club sold Andy Carroll to Liverpool during the January transfer window for a record ?35million.
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