"We know it's going to be a very tough game at Anfield," Shearer told reporters today as he prepared his team to face a side who won 5-1 on Tyneside last December.
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"Can we keep them out? Tall order but if we do, we have to take our one chance.
"We've had a few good days' training on the way we're going to go in (to the match) and that's encouraged everyone.
"There have been a few teams, Hull, Fulham, Stoke, who have gone to Anfield and come back with points - we'll be looking to do the same.
"Some will say that the pressure is off, but I've got to instill into my players that we can go there and get something."
Newcastle are currently third-bottom of the Premier League and Shearer is banking on his trio of strikers - Obafemi Martins, Mark Viduka and Liverpool old boy Michael Owen - to come good on Merseyside following a 0-0 against Portsmouth at St James' Park.
"We'll get one chance, at least," Shearer said. "I know we haven't got a lot of time so when they come along we have to take them.
"The pleasing thing for me the other night was that we created chances. The disappointing thing is that we didn't take them. I said in the previous games that I was concerned that we didn't create the chances.
"Now I know that if we keep creating the chances, with the calibre of strikers such as Owen, Viduka and Martins that eventually they'll go in."
He added: "Michael was as disappointed with his miss as anyone the other night.
"But it would not be fair to not mention the ones from Oba and Mark - they were equally disappointing.
"If we do create a chance I'll be looking for one of them guys to put it in."