Papiss Cisse repeated his injury-time heroics to head Newcastle into the Europa League quarter-finals as 10-man Anzhi Makhachkala finally succumbed to a 1-0 defeat.
The Senegal international, who fired the Magpies to a 2-1 Barclays Premier League win over Stoke on Sunday with a 92nd-minute strike, had to wait two minutes longer to power home Sylvain Marveaux's inviting cross with the final touch of an intriguing contest.
Anzhi, who had midfielder Mehdi Carcela-Gonzalez sent off in the second half, came close with two minutes of normal time remaining when Mbark Boussoufa's free-kick came back off Rob Elliot's crossbar.
But on a night of high drama on Tyneside, Alan Pardew's men booked their place in Friday's draw for the last eight in Nyon in front of a crowd of 45,487. The momentum was largely with Anzhi in the first half and had it not been for Magpies defender Steven Taylor, they could have taken the lead on several occasions.
Taylor kept Lassana Diarra at bay three times inside two minutes with the midfielder being allowed to run deep into enemy territory unchecked - and he put his body on the line once again with 28 minutes gone to prevent Silva Jucilei's firmly-struck drive reaching Elliot.
Taylor also headed a Sylvain Marveaux free-kick high over at the end of the first half, but Newcastle headed for the dressing rooms knowing they had been comfortably second-best.
The home side returned in determined fashion and Moussa Sissoko headed Davide Santon's cross over within seconds of the restart. The former Toulouse midfielder should have done better four minutes later when he failed to connect with Marveaux's inviting cross in front of goal.
Newcastle should have been ahead with 52 minutes gone when Marveaux's free-kick came off Papiss Cisse and fell nicely for Taylor - but the defender could only stab the ball straight at Vladimir Gabulov. The momentum had shifted and it moved further in the Magpies' direction three minutes later when Mehdi Carcela-Gonzalez caught Massadio Haidara and received a second yellow card.
Vurnon Anita was perhaps fortunate to escape with only a caution for his challenge on Yuri Zhirkov, but the visitors made light of their numerical disadvantage when Samuel Eto'o controlled a long ball and lifted a 59th-minute shot over Elliot's crossbar.
Cheick Tiote smashed a long-range effort just over 15 minutes from time with the home side dominating possession, but Eto'o forced a vital near-post save from Elliot seven minutes later. The Magpies got lucky when Boussoufa rattled the crossbar with a free-kick from 22 yards with Elliot beaten, before they won the tie with the last touch of the game when Cisse powered Marveaux's cross past Gabulov.