The march has been arranged by the Time 4 Change group and sanctioned by local authorities.
But how many will attend?
This will be make-or-break for the Time 4 Change group. If 1,000 attend it will be seen as a major success, but low numbers would be disaster to the organisers.
Newcastle fans attending the fixture have also been encouraged to wave white handkerchiefs as the teams take the pitch before kick-off.
The protest's organisers believe leadership change at St James' Park is essential. "We have felt the utter frustration, like many other fans, at the way the club has been run by Mike Ashley," said Time 4 Change in a statement.
Ashley's reign has been overshadowed by a string of controversies which have upset supporters including the temporary re-naming of St James' Park, a lack of activity in the transfer market and Joe Kinnear's appointment as director of football.
Supporters are being asked to meet on the pedestrian area of Northumberland Road next to the City Hall at 10.30am, with the march to pass through the city centre, past St James' Park and finish at the bandstand in Leazes Park.
Chris McQuillan, a Time 4 Change spokesman, said: "If we could get 1,000-plus on the day that would be a massive success.
"Nobody expects Ashley to look at people marching past the stadium and simply run away. However, this will give us a platform and we can move on from there."
Source: Newcastle United Mad