Holland coach Bert van Marwijk fears Dirk Kuyt could face a lengthy spell on the sidelines after picking up an ankle injury in the 4-1 win over Sweden.
The Liverpool forward lasted just 28 minutes of the Euro 2012 qualifier and was taken to hospital in an ambulance with what looked a serious injury.
Van Marwijk has yet to receive a full diagnosis but admitted: "It does not look good."
That is the last thing Liverpool boss Roy Hodgson wants to hear as he prepares for the weekend's Merseyside derby at Everton.
The Reds travel to Goodison Park on Sunday while sat uncomfortably in the bottom three of the Barclays Premier League.