Morecambe play their first game at the Globe Arena with Coventry the visitors in the Carling Cup first-round clash.
The Shrimps lost their first match of the season on Saturday in a 2-0 defeat at the hands of npower League Two rivals Wycombe.
Now boss Sammy McIlroy is set to hand home debuts to several new signings after four new faces featured against the Chairboys.
Chris Shuker, Paul Scott, Adam Rundle and Chris McCready all started the match and will hope to keep their places.
Former Tranmere midfielder Shuker last week signed a one-year deal following his release from Prenton Park and McIlroy is expecting big things of him.
The Shrimps manager said: "Chris is an experienced player who will bring a lot to the squad."